Gather-ed - Curriculum Registration

Credits Available:

4.25 AMA PRA Category 1 Credit™; ABIM MOC

Description: Rigorous clinical research has led to the discovery of novel immunologic therapies. Chimeric antigen receptor T cell (CAR T-cell) therapy has shown impressive outcomes but is associated with a significant risk of adverse events (AEs), chiefly cytokine release syndrome (CRS). Bispecific antibodies act through a similar mechanism of action but offer a lower risk of CRS. These AEs may require immediate management, which may occur in the emergency department (ED) setting.

Given the novelty and specialty nature of bispecific antibody and CAR T-cell therapies, ED clinicians face several challenges in the practical management of patients receiving these therapies. Similarly, given the breadth of conditions treated with these therapies, ED clinicians may face difficulties knowing which patient populations are at risk. While CAR T therapies are approved for hematologic malignancies, bispecific antibodies are approved for many indications including hematologic malignancies, non-small cell lung cancer, uveal melanoma, hemophilia A, and neovascular macular edema. This collaborative social learning platform establishes a network of providers who can create a sustainable network of providers who can continue to support each other following this experience in implementing their practice action plans aimed at improving the care provided to patients on CAR T or bispecific therapies.

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Target Professions:	DO, MD, Nurse, Nurse Practitioner, Physician Associate/Assistant
Target Specialties:	Emergency Medicine, Oncology

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Joseph Oropeza

UCHealth Memorial Hospital Central
Emergency Medicine Clinical Pharmacist

Joe is an Emergency Medicine and Critical Care Pharmacy Clinical Specialist at the University of Colorado Health. He enjoys fostering two-way learning by not only contributing expertise but also engaging in continuous learning from colleagues and experiences. He takes pride in teaching and mentoring future learners emphasizing critical thinking, problem-solving skills, and the importance of shared decision-making in clinical scenarios.

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On the front lines - Managing CRS in the Emergency Department

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Joseph Oropeza