Title: “New Frontiers with BCMA Targeting in the Treatment of Heavily Relapsed Multiple Myeloma”

Presented by: Johns Hopkins University School of Medicine

Release Date: November 21, 2023
Expiration Date: November 21, 2024

Estimated time to complete this activity: 5 hours. This activity has been approved for a maximum of 5.0 AMA PRA Category 1 Credits™.

Fees and Prerequisites: There are no fees or prerequisites.

Acknowledgement of Commercial Support: Supported by an independent educational grant from Pfizer Inc.

Target Audience

This activity is intended to meet the educational needs of hematologists/ oncologists involved in the treatment of patients with RRMM.

Learning Objectives

After participating in this activity, learners will demonstrate the ability to:

• Apply foundational understanding of the mechanism of action and target of BCMA therapies to patient discussions and clinical practice.
• Use knowledge of the latest clinical data on BCMA therapies in RRMM, including key trials, efficacy insights, and side effect profiles in clinical decision making.
• Use guideline recommendations and expert guidance for the use of MRD in response assessment and therapy management for RRMM.
• Use practical approaches to patient discussion when considering utilizing BCMA targeted therapies for patients with RRMM.

Presented by Johns Hopkins University School of Medicine

                
Accreditation Statement

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Johns Hopkins University School of Medicine and Medical Logix, LLC. The Johns Hopkins University School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation Statement

The Johns Hopkins University School of Medicine designates this other activity (live and self-study digital modules) for a maximum of 5.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Other Credits

American Nurses Credentialing Center (ANCC) accepts AMA PRA Category 1 CreditTM from organizations accredited by the ACCME.

American Association of Nurse Practitioners National Certification Program accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.

American Academy of PAs (AAPA) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. PAs may receive a maximum of 5.0 AAPA Category 1 Credit for completing this program.

Statement of Need

Multiple myeloma (MM) is a clonal plasma cell disorder arising from the bone marrow and is the second most common hematologic malignancy in the United States (US), with an incidence of approximately 35,000 new cases per year. While progression-free survival (PFS) benefit is often seen with MM therapeutics, overall survival (OS) benefit is rarely seen with novel therapies, and improvements in PFS are still associated with adverse events and long-term disease refractoriness. Over the past few decades, rigorous pre-clinical and clinical research has led to the discovery of novel therapies that have dramatically changed the treatment landscape of MM in the frontline as well as in the relapsed/refractory setting. Despite implementing multimodal approaches to treat MM, the major challenge remains that the vast majority of patients eventually relapse and become refractory to multiple drug classes. Additionally, patients require continuous treatment throughout the disease course, which can negatively affect their quality of life due to potential therapy-related side effects. This collaborative social learning platform establishes a network of providers who can support each other locally, as well as those from different communities, with the goal of learning and sharing best practices that will improve outcomes for patients with multiple myeloma.

Policy on Presenter and Provider Disclosure

It is the policy of the Johns Hopkins University School of Medicine and the Institute for Johns Hopkins Nursing that the presenter and provider globally disclose conflicts of interest. The Johns Hopkins University School of Medicine OCME has established policies in place that will identify and mitigate relevant conflicts of interest prior to this educational activity. Detailed disclosure will be made prior to presentation of the education.

Format and Method of Participation

Review this internet-based CME activity. To take the post-test, please click on the post-test button below the video window of the player which will take you to the Johns Hopkins School of Medicine’s website. If you already have registered for other programs at this website, simply enter the requested information when prompted. Otherwise, complete the registration form to begin the testing process. The information you enter here will be used to generate your CME certificate. Please complete all fields to ensure accurate registration. Complete the post-test and evaluation and attest to the amount of time spent in the activity. Upon receiving a score of 70% or above, print your CME certificate.

Full Disclosure Policy Affecting CME Activities

As a provider approved by the Accreditation Council for Continuing Medical Education (ACCME), Johns Hopkins School of Medicine Office of Continuing Medical Education (OCME) requires attested and signed global disclosure of the existence of all financial interests or relationships with ineligible companies from any individual in a position to control the content of a CME activity sponsored by OCME. The following relationships have been reported for this activity:

Faculty
Syed Abbas Ali, MBBS – Activity Director/Author/Presenter - Grant or research support: Bristol-Myers Squibb; Pfizer, Inc., Honoraria: Curio Science, Vaniam Group

No one else in a position to control the content of this educational activity has disclosed a relevant financial interest or relationship with an ineligible company. All relevant conflicts of interest have been mitigated prior to the commencement of the activity.

Note: Grants to investigators at The Johns Hopkins University are negotiated and administered by the institution which receives the grants, typically through the Office of Research Administration. Individual investigators who participate in the sponsored project(s) are not directly compensated by the sponsor, but may receive salary or other support from the institution to support their effort on the project(s).

MITIGATION OF RELEVANT FINANCIAL RELATIONSHIPS

Johns Hopkins University adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers or others are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.

Johns Hopkins Statement of Responsibility

The Johns Hopkins School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity.

Copyright

All rights reserved - The Johns Hopkins School of Medicine. No part of this program may be used or reproduced in any manner whatsoever without written permission except in the case of brief quotations embodied in articles or reviews.

Internet CME Policy

The Office of Continuing Medical Education (OCME) at the Johns Hopkins School of Medicine is committed to protecting the privacy of its members and customers. Johns Hopkins School of Medicine OCME maintains its Internet site as an information resource and service for physicians, other health professionals and the public. OCME at the Johns Hopkins School of Medicine will keep your personal and credit information confidential when you participate in a CME Internet based program. Your information will never be given to anyone outside of the Johns Hopkins School of Medicine CME program. CME collects only the information necessary to provide you with the services that you request.

Disclaimer

The opinions and recommendations expressed by faculty and other experts, whose input is included in this program are their own. This other activity/live and self-study digital modules is produced for educational purposes only. Use of the Johns Hopkins School of Medicine name implies review of educational format design and approach. Please review the complete prescribing information of specific drugs or combinations of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.

AMERICANS WITH DISABILITIES ACT

The Johns Hopkins School of Medicine fully complies with the legal requirements of the ADA and the rules and regulations thereof. Please notify us if you have any special needs.

COURSE FORMAT – METHOD OF PARTICIPATION

This other/activity/live and self-study digital modules is expected to take approximately 5 hours to complete. Once the activity is completed, you must pass the post-test and complete the evaluation with attestation to receive CME credit.

POST-TEST

A post-test will be conducted at the conclusion of the activity. A grade of at least 70% within three attempts is needed to receive CME credit.

Faculty

Syed Abbas Ali, MBBS
Assistant Professor of Oncology
Department of Oncology, Hematologic Malignancies
Johns Hopkins School of Medicine
Baltimore, MD

Off-Label Discussion

There are no references to off-label/unapproved uses of products in this program.

Confidentiality Disclaimer for CME Activity Participant

I certify that I am participating in this Johns Hopkins School of Medicine activity for CME-accredited training and/or educational purposes.

I understand that while I am participating in this capacity, I may be exposed to "protected health information," as that term is defined and used in Hopkins policies and in the federal HIPAA privacy regulations (the “Privacy Regulations”). Protected health information is information about a person's health or treatment that identifies the person.

I pledge and agree to use and disclose any of this protected health information only for the training and/or educational purposes of my visit and to keep the information confidential. I agree not to post or discuss this protected health information, including pictures and/or videos, on any social media site (eg, Facebook, Twitter, etc.), in any electronic messaging program or through any portable electronic device.

I understand that I may direct to the Johns Hopkins Privacy Officer any questions I have about my obligations under this Confidentiality Pledge or under any of the Hopkins policies and procedures and applicable laws and regulations related to confidentiality. The contact information is:  Johns Hopkins Privacy Officer, telephone: 410-614-9900 , e-mail: HIPAA@jhmi.edu.

“The Office of Continuing Medical Education at the Johns Hopkins School of Medicine, as sponsor of this activity, has relayed information with the CME attendees/participants and certify that the visitor is here for training, education and/or observation purposes only.”

For CME questions, please contact the CME Office 410-955-2959  or email cmenet@jhmi.edu.
For CME Certificates, please call (410) 502-9636.

Johns Hopkins School of Medicine
Office of Continuing Medical Education
720 Rutland Avenue/ Turner 20
Baltimore, Maryland 21205-2195
Reviewed & Approved by: General Counsel, Johns Hopkins Medicine (4/1/03)
(Updated 4/09 and 3/14)