Time Commitment: 4 hours over 56 days
Target Professions: DO, MD, Nurse, Nurse Practitioner, Physician Assistant
Target Specialties: Family Medicine, Internal Medicine, Gastroenterology, Hematology, Hematology/Oncology, Oncology, Colorectal Surgery
Credits Available: 4.0 AMA PRA Category 1 Creditâ„¢

Colorectal cancer (CRC) continues to be the second most lethal cancer in the United States (US) with approximately 149,500 new cases and 52,980 deaths per year. Patients diagnosed at an advanced/metastatic stage have a five-year survival rate of roughly 14%. For these patients, initial treatment is usually chemotherapy based. With this treatment, patients have a median survival of 30 months. Through further research, targeted therapies have been developed to fight metastatic CRC (mCRC), these include antibodies against the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF). These agents have increased overall survival (OS) in mCRC.
Several biomarkers are used in the diagnosis of mCRC, including KRAS and MRAF mutations as well as microsatellite instability assessment. Testing for and targeting BRAF mutations is recommended by the National Comprehensive Cancer Network (NCCN) guidelines. Still BRAF testing is underused, especially at community centers. While BRAF V600E mutation is associated with poorer prognosis, there are now targeted treatments available. After first-line treatment, subsequent systemic therapy recommendations from the NCCN include the combination of encorafenib in addition to EGFR inhibition with cetuximab or panitumumab. Dermatologic adverse events (AEs), among others, may occur with these treatments, but there is detailed guidance available for their management.
This educational program will help clinicians understand the importance of BRAF testing and treatment with practical guidance on managing AEs to keep patients on effective doses of their needed medications.

CME/CE Accreditation Information

Self Study

Live Group Discussions

  • #1: Key Insights on mCRC

    This virtual live discussion will offer an interactive approach to providing optimal care to patients with metastatic colorectal cancer.

  • #2: mCRC Take-Home Messages: Putting the Evidence to Practice

    This virtual live discussion will focus on reviewing the patient cases and how the findings apply to caring for current or future patients with metastatic colorectal cancer. Action plans will also be presented as we reflect on change of practice as a result of this CME activity.

Group Challenge

  • Metastatic Colorectal Cancer Group Challenge: Rosaline's Case Part 1

    This group task activity has been designed for the learner to explore a patient case study and to apply the knowledge they have learned throughout the activity to determine the most appropriate way to treat the patient.

  • Metastatic Colorectal Cancer Group Challenge: Rosaline's Case Part 2

    This group task has been designed for the learner to explore a patient case study and to apply the knowledge they have learned throughout the activity to determine the most appropriate way to treat the patient.

My Action Plan

  • Your Action Plan

    In light of the information reviewed and discussed during this program, can you share an action plan that you will implement to improve the outcomes for your patients with metastatic CRC.

Interested in becoming a Group Leader?

Experts in the management of patients with metastatic colorectal cancer, including physicians and advanced practice providers. Apply Now

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Completed Groups

Benjamin Weinberg, MD
Associate Professor of Medicine
Neha Varshney, MD
Associate Director of Surgical Pathology
Maliha Nusrat, MD/ MBBS
Assistant Attending Physician, Gastrointestinal Medical Oncology
Aparna Parikh, MD
Deepak Vadehra, DO
Cassandra Vonnes, DNP, GNP AOCNP
Diana Tamer, PharmD, BCOP
Clinical Assistant Professor
Divine Chi, PharmD
Oncology Clinic Pharmacist
Marie Sirek, PharmD, BCACP, CPP
Clinical Pharmacist - Oral Oncology
Nikki Kahler, DNP, CRNP
Nurse Practitioner
Eric Lander, MD
Clinical Fellow
Abigail Shockley, PharmD
Clinical Pharmacy Specialist
Megan Fonteno, PharmD
Sarcoma/Melanoma Clinical Pharmacist
Valentia Sterlin, NP MSN
NP hematology oncology
Kathryn Bacci, PA-C
Physician Assistant
Samuel Kareff, MD, MPH
Hematology/Oncology Chief Fellow
Jeff Ye, MD